Posted by: 4pack | June 25, 2008

You And Your Liver…Trust Me, You Don’t Want A Fatty Liver

A successful campaign (PETA?) was waged against the forced feeding of geese to cause their livers to fairly explode with fat and therefore producing the very finest flavor for Pate de Foie Gras….where is the outrage at the “forced feeding” of our “bubbas”…ladies, surely you can muster up enough disgust to comment on what can only be the American version of the self-described Australian Fat Bomb…

(…by the way, Pate Mousse Truffe is outstanding with a fine Burgundy, possibly a 2002 Gevrey-Chambartin)

Fatty Liver                                           

The Liver
The liver is the largest organ in the body. It is found high in the right upper abdomen, behind the ribs. It is a very complex organ and has many functions. They include:

  • Storing energy in the form of sugar (glucose)
  • Storing vitamins, iron, and other minerals
  • Making proteins, including blood clotting factors, to keep the body healthy and help it grow
  • Processing worn out red blood cells
  • Making bile which is needed for food digestion
  • Metabolizing or breaking down many medications and alcohol
  • Killing germs that enter the body through the intestine

The liver shoulders a heavy workload for the body and almost never complains. It even has a remarkable power to regenerate itself. Still it should not be taken for granted. Certain conditions that develop, such as fatty liver and steatohepatitis, may be signs of liver injury that can lead to permanent liver damage.

What is Fatty Liver?
Fatty liver is just what its name suggests: the build-up of fat in the liver cells. Although this is not a normal condition, fat in the liver usually causes no damage by itself. However, on some occasions it can be a sign that other more harmful conditions are at work. Fatty liver may be associated with or may lead to inflammation of the liver. This can cause scarring and hardening of the liver. When scarring becomes extensive, it is called cirrhosis, and this is a very serious condition. Therefore, it is important that a physician thoroughly examine a patient with fat in the liver.

Cause
It would seem logical that eating fatty foods would cause a fatty liver, but this is not the case. The liver does play an important role in the metabolism or breakdown of fats. Something goes wrong in this process of metabolism, but it is still not known what does cause fat to build-up in the liver. It is known that fat accumulates in the liver with a number of conditions. The most common is obesity. Fatty liver is also associated with diabetes mellitus, high blood triglycerides, and the heavy use of alcohol. It may occur with certain illnesses such as tuberculosis and malnutrition, intestinal bypass surgery for obesity, excess vitamin A in the body, or the use of certain drugs such as valproic acid (trade names: Depakene/Depakote) and corticosteroids (cortisone, prednisone). Sometimes fatty liver occurs as a complication of pregnancy.

Symptoms and Diagnosis
There are usually no symptoms that are noticeable to the patient. In fact, fatty liver is frequently uncovered during a routine physical examination. There may be a rise in certain liver enzymes found in the blood, and sometimes the liver is slightly enlarged. Fatty liver may also be discovered while the physician is evaluating a patient for other illnesses. For example, an ultrasound exam of the abdomen done for other reasons may show fat in the liver. To be certain of a diagnosis of fatty liver, the physician may recommend a liver biopsy. Under local anesthesia, a slender needle is inserted through the right lower chest. A small piece of liver tissue is taken out with the needle and examined under a microscope.

What is Steatohepatitis?
The term hepatitis means inflammation of and damage to the liver cells. Steato (pronounced stee-at´-toe) refers to fat. Therefore, steatohepatitis is inflammation of the liver related to fat accumulation. Heavy alcohol use can lead to fatty liver and inflammation, usually called alcoholic hepatitis. Steatohepatitis resembles alcoholic hepatitis, but it can and does occur in people who seldom or never drink alcohol. In this instance, it is often called nonalcoholic steatohepatitis or NASH. Both alcoholic hepatitis and steatohepatitis can lead to serious liver damage and cirrhosis.

Studies have shown that many people who are significantly overweight have developed, or will develop, steatohepatitis. It can also occur with rapid weight loss. Steatohepatitis has been connected to estrogen hormones in some women. In the case of diabetes mellitus, researchers believe steatohepatitis may develop only in those patients whose diabetes is not properly controlled.

Treatment
In most instances, treatment of fatty liver and steatohepatitis requires control of the underlying conditions. This may include reduction of high blood triglycerides, good control of diabetes, or not drinking alcohol. In some cases, surgical reversal of intestinal bypass for obesity is required.

Since being overweight is by far the most critical factor, weight loss is the key to ridding the liver of fat. This is especially necessary if damage to the liver is occurring, and early signs of scarring are present on biopsy. High blood triglycerides and diabetes are also worse with obesity. So, when steatohepatitis is present with these conditions, people gain even greater benefits from losing weight. Losing weight can be difficult. However, it must be done because the alternative may be eventual cirrhosis and the need for a liver transplant.

Currently, studies are underway on certain drugs such as Actigall. This drug appears to reduce liver damage in cases of steatohepatitis. At this time, however, it is not certain how helpful these drugs will be. To repeat the point, losing weight is by far the most important treatment.

Liver Transplantation
Liver transplantation is now an accepted form of treatment for chronic, severe liver damage. Advances in surgical techniques and the use of new drugs to suppress rejection have dramatically improved the success rate. Steatohepatitis is one of the more uncommon reasons for a liver transplant. However, every transplant center does a few each year as a result of this disease. Survival rates at transplant centers are well over 90% with a good quality of life after recovery.

Summary
Fatty liver is simply the build-up of fat in the liver. Fat in the liver usually does not cause liver damage. However, certain other conditions and diseases can be associated with the development of fatty liver. Research is ongoing to uncover what processes may take place to trigger fat build-up in the liver. This condition is usually reversible when the underlying causes are treated or removed. Patients who follow the advice of their physicians can expect to reverse and control a fatty liver or steatohepatitis.

(From Jackson Siegelbaum Gastroenterology  website)

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Responses

  1. I just read this blog and interesting enough I have been diagnosed with sgpt numbers of 120. I don’t drink, smoke, and am not an overweight person. I did have optic neuritis in 2003 and was administered 1000 mg’s of sterioids in the veins for 3 day’s making it 3000 mg’s. I also, was a victom of Baycol in the year 2000 that caused me to loose 4 dress sizes in 3 months. At a size one my doctor took me off of Baycol and ran several test. I never have been the same with my energy . The doctor of course say’s all test were normal. I found out that Baycol was taken off the market in 2001 due to approx. 52 deaths. I’m lucky I wasn’t number 53. I will alway’s believe it damaged me in some way. My whole body went down hill after that. Bayco is a statin drug. Today, I am wondering if it could have damaged something and is just now showing up. Just a thought… Just had a ultra sound 2 days ago on the liver, kidneys , aorta, and am waiting on test. My doctor says that I am the 3rd person in a month with this condition. I ask what their diagnosis was and it was Fatty Liver.


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